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Your Ad Here Clayton County, Georgia Clayton County is a county located in the U.S. state of Georgia. The 2006 Census Estimate placed the population at 271,240. The county seat is Jonesboro. History The county was formed in 1858 and was named in honor of Augustus Smith Clayton (1783-1839), who served in the United States House of Representatives from 1832 till 1835. ![]() |